Tracking Single Particles Using Surface Plasmon Leakage Radiation Speckle

Label free tracking of small bio-particles such as proteins or viruses is great utility in the study biological processes, however experiments are frequently hindered by weak signal strengths and a susceptibility to scattering impurities. To overcome these problems we here propose novel technique leveraging enhanced sensitivity both interferometric detection strong field confinement surface plasmons. Specifically, show that interference between scattered an analyte particle speckle reference field, derived from random plasmons propagating on rough metal film, enables with sub-wavelength accuracy. We present analytic framework our verify its robustness noise through Monte Carlo simulations.